ISRIB
C₂₂H₂₄Cl₂N₂O₄
The foundational ISRIB molecule discovered at UCSF. Selectively targets the ISR pathway via eIF2B modulation.
- Discovered at UCSF (2013)
- ≥98% HPLC purity, COA per batch
- ¹H / ¹³C NMR verified every batch
- Free worldwide shipping on all orders
Molecular formula: C₂₂H₂₄Cl₂N₂O₄
Order
ISRIB
Original MoleculeSelect format
Select quantity
Min 100mg · Max 30g · larger orders arranged individually
- Quantity
- 1g (1000mg)
- Price per gram
- $100/g
- COA available per batch on request
- Worldwide shipping
- Secure packaging
- Support via Email/Telegram/Signal
- Payments arranged individually
The science · eIF2B
ISRIB — the original ISR inhibitor.
ISRIB was reported by Peter Walter's group at UCSF to restore learning & memory in brain-injured and elderly mice by modulating the Integrated Stress Response via eIF2B. Featured in peer-reviewed journals (Science, eLife, Nature).
ISR activation
Stress triggers eIF2α phosphorylation and translation shut-down.
eIF2B modulation
ISRIB binds eIF2B to counteract the inhibition.
Cognitive restoration
Protein synthesis resumes to support plasticity & memory.
ISRIB vs ISRIB A15
| ISRIB | ISRIB A15 | |
|---|---|---|
| Research history | Original discovery | Optimized analog |
| Effective dose | 50+ mg | 5–15 mg |
| Bioavailability | Moderate | Enhanced |
| Research applications | Extensive | Growing |
| Cost per study | Lower | Higher |
ISRIB remains the gold standard for research applications where established protocols and extensive literature support are essential.
NMR characterization
Every batch is characterised by ¹H and ¹³C NMR. We publish both the processed spectra and the raw FID data so any researcher can independently verify the structure and purity of what they receive — compatible with MestReNova, TopSpin, and other standard NMR software. COA available per batch on request.
Download raw FID data
We don't just show you pictures. Download the original spectrometer output and process it yourself in MestReNova, TopSpin, or any compatible NMR software. Every peak, every integration — fully verifiable.
Technical specifications
Chemical properties
- Formula
- C₂₂H₂₄Cl₂N₂O₄
- MW
- 451.3 g/mol
- CAS
- 1597403-47-8
- Purity
- ≥98% (HPLC)
- Form
- White to off-white powder
- Solubility
- DMSO
Storage & handling
- Storage
- -20°C
- Stability
- 2+ years
- Light
- Store in dark
- Moisture
- Keep dry
- Container
- Amber glass vial
Documentation
- COA
- On request
- ¹H NMR
- Available
- ¹³C NMR
- Available
- Safety data
- Provided
- COA available per batch on request
- Worldwide shipping
- Secure packaging
- Support via Email/Telegram/Signal
- Payments arranged individually