2‑Methyl‑6‑(phenylethynyl)pyridine · Oxalate
Selective negative allosteric modulator of mGluR5. High specificity and potency.
MPEP (2-methyl-6-(phenylethynyl)pyridine) is a highly selective negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its exceptional selectivity and potency have made it an indispensable tool in glutamate research.
As a negative allosteric modulator (NAM), MPEP binds to a site distinct from the glutamate binding site, providing non-competitive inhibition that offers unique research advantages over competitive antagonists.
MPEP binds to the transmembrane domain of mGluR5, distinct from the glutamate binding site.
Non-competitive inhibition blocks mGluR5-mediated signaling pathways.
Modulates synaptic plasticity, neuronal excitability, and behavioral responses.
Study mGluR5’s role in cognition and memory formation
Investigate mGluR5-dependent LTP/LTD mechanisms
Autism, schizophrenia, addiction models with glutamatergic dysfunction