C₂₂H₂₂Cl₄N₂O₄
Ultra‑potent ISRIB analogue with enhanced bioavailability. Targets eIF2B.
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✅ Both compounds included • Free worldwide shipping • 15% bundle discount
Originally discovered by Peter Walter’s team at UCSF, ISRIB restored learning & memory in brain‑injured and elderly mice. A15 is an optimized analog with improved potency and PK, tuned for oral bioavailability.
Featured across peer‑reviewed literature (Science, eLife, Nature).
Stress/aging triggers the Integrated Stress Response.
A15 binds eIF2B, stabilizing translation despite stress signals.
Neurons resume protein synthesis required for memory & plasticity.
| Feature | ISRIB A15 | Original ISRIB |
|---|---|---|
| Potency | 10x Higher | Baseline |
| Effective Dose | 5–15 mg | 50+ mg |
| Oral Bioavailability | Enhanced | Limited |
| Solubility | Improved | Poor |
| Cost per Effect | Lower | Higher |