Chemical formula of ISRIB A15
Molecular formula: C₂₂H₂₂Cl₄N₂O₄
98%+
Purity
COA
Per batch
2013
UCSF discovery
Most Popular ✓ In stock

ISRIB A15

C₂₂H₂₂Cl₄N₂O₄

Ultra‑potent ISRIB analogue with enhanced bioavailability. Targets eIF2B.

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ISRIB A15

Ultra Potent Analog
Purity:≥98% (HPLC)
COA:Included

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Trial
100mg
$60
Trial
500mg
$130
Standard
1g
$200/g
⭐ Popular
2g - 4g
$180/g
Save 10%
Serious Users
5g - 9g
$170/g
Save 15%
Bulk
10g - 30g
$160/g
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Min: 100mg • Max: 30g • For larger orders, contact us
Total Price: $200.00
Quantity: 1g (1000mg)
Price per gram: $200.00/g
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🔥 Frequently bought together

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ISRIB A15
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Regular: $100.00
Bundle: $85.00
Save $15 (15% off)

✅ Both compounds included • Free worldwide shipping • 15% bundle discount

The Science behind ISRIB A15

🔬 Discovery at UCSF

Originally discovered by Peter Walter’s team at UCSF, ISRIB restored learning & memory in brain‑injured and elderly mice. A15 is an optimized analog with improved potency and PK, tuned for oral bioavailability.

🧬

Published Research

Featured across peer‑reviewed literature (Science, eLife, Nature).

How A15 Works

1

ISR Activation

Stress/aging triggers the Integrated Stress Response.

2

eIF2B Enhancement

A15 binds eIF2B, stabilizing translation despite stress signals.

3

Cognitive Restoration

Neurons resume protein synthesis required for memory & plasticity.

Why ISRIB A15 Over Original ISRIB?

Feature ISRIB A15 Original ISRIB
Potency 10x Higher Baseline
Effective Dose 5–15 mg 50+ mg
Oral Bioavailability Enhanced Limited
Solubility Improved Poor
Cost per Effect Lower Higher

💡 ISRIB A15 delivers similar cognitive benefits at much lower doses with better absorption and cost‑effectiveness.

Technical Specifications

🧪 Chemical Properties

Formula:C₂₂H₂₂Cl₄N₂O₄
MW:520.24 g/mol
Purity:≥98% (HPLC)
Form:White/off‑white powder
Solubility:DMSO

📦 Storage & Handling

Storage:-20°C
Stability:2+ years
Light:Store in dark
Moisture:Keep dry
Container:Amber glass vial

📋 Documentation

COA:✓ Included
¹H NMR:✓ Available
Mass Spec:✓ Available
Safety Data:✓ Provided