C₂₂H₂₄Cl₂N₂O₄
The foundational ISRIB molecule discovered at UCSF. Selectively targets the ISR pathway via eIF2B modulation.
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ISRIB was reported by Peter Walter’s group at UCSF to restore learning & memory in brain‑injured and elderly mice by modulating the Integrated Stress Response via eIF2B.
Featured in peer‑reviewed journals (Science, eLife, Nature).
Stress triggers eIF2α phosphorylation and translation shut‑down.
ISRIB binds eIF2B to counteract the inhibition.
Protein synthesis resumes to support plasticity & memory.
| Feature | ISRIB | ISRIB A15 |
|---|---|---|
| Research History | Original Discovery | Optimized Analog |
| Effective Dose | 50+ mg | 5–15 mg |
| Bioavailability | Moderate | Enhanced |
| Research Applications | Extensive | Growing |
| Cost per Study | Lower | Higher |