Chemical formula of ISRIB
Molecular formula: C₂₂H₂₄Cl₂N₂O₄
98%+
Purity
COA
Per batch
2013
UCSF discovery
Original Formula ✓ In stock

ISRIB

C₂₂H₂₄Cl₂N₂O₄

The foundational ISRIB molecule discovered at UCSF. Selectively targets the ISR pathway via eIF2B modulation.

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ISRIB

Original Molecule
Purity:≥98% (HPLC)
COA:Included

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Min: 100mg • Max: 30g • For larger orders, contact us
Total Price: $100.00
Quantity: 1g (1000mg)
Price per gram: $100.00/g
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🔥 Frequently bought together

Researchers who bought this also ordered:

✓
ISRIB
ISRIB 100mg $27.00
+
ISRIB A15
ISRIB A15 100mg $50.00
=
Regular: $77.00
Bundle: $65.45
Save $11.55 (15% off)

✅ Both compounds included • Free worldwide shipping • 15% bundle discount

The Science behind ISRIB

🔬 Discovery at UCSF

ISRIB was reported by Peter Walter’s group at UCSF to restore learning & memory in brain‑injured and elderly mice by modulating the Integrated Stress Response via eIF2B.

🧪

Published Research

Featured in peer‑reviewed journals (Science, eLife, Nature).

How ISRIB Works

1

ISR Activation

Stress triggers eIF2α phosphorylation and translation shut‑down.

2

eIF2B Modulation

ISRIB binds eIF2B to counteract the inhibition.

3

Cognitive Restoration

Protein synthesis resumes to support plasticity & memory.

ISRIB vs ISRIB A15

Feature ISRIB ISRIB A15
Research History Original Discovery Optimized Analog
Effective Dose 50+ mg 5–15 mg
Bioavailability Moderate Enhanced
Research Applications Extensive Growing
Cost per Study Lower Higher

💡 ISRIB remains the gold standard for research applications where established protocols and extensive literature support are essential.

Technical Specifications

🧪 Chemical Properties

Molecular Formula:C₂₂H₂₄Cl₂N₂O₄
Molecular Weight:451.3 g/mol
CAS Number:1597403-47-8
Purity:≥98% (HPLC)
Form:White to off-white powder
Solubility:DMSO

📦 Storage & Handling

Storage Temp:-20°C
Stability:2+ years
Light Sensitivity:Store in dark
Moisture:Keep dry
Container:Amber glass vial

📋 Documentation

COA:✓ Included
¹H NMR:✓ Available
Mass Spec:✓ Available
Safety Data:✓ Provided